Neo-Scholastic metaphysics plays an outstanding role in 17th century philosophy. The beginnings of the modern scientific view of the world originate from precisely the same time. With reference to the anatomist Francis Glisson (ca. 1597-1677), this study investigates the significance of school metaphysics for the inception of a new form of natural philosophy. It shows that Glisson developed a retrospective theory of substance from his identity as a scientist. In so doing, it casts a surprising light on the formative intellectual conditions governing the emergence of the sciences in the modern age.
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