FASTtrack: Chemistry of Drugs

Cover; Title Page; Copyright; Contents; Introduction To The Fasttrack Series; Preface; About The Authors; Chapter 1. Chemical Structure And Bonding; Cations And Anions; Electron Orbitals; Electronic Configuration; Molecular Orbitals; Promotion; Hybridisation; Bonding; Valence Shell Electron Pair Repulsion (vsepr); Nucleophiles And Electrophiles; Drawing Chemical Structures; Resonance/mesomerism; Drawing Resonance Hybrids; Self-assessment; Chapter 2. Intermolecular Interactions; Importance Of Intermolecular Interactions In Pharmacy; Coulombic/electrostatic Interactions. Examples Of Nucleophilic Additionaddition Of Amines -- Imine And Enamine Formation; Reductive Amination; Addition-elimination; Changes In Hybridisation During Addition-elimination; Examples Of Addition-elimination; α-hydrogen Reactivity; Examples Of α-hydrogen Reactions; Conjugate Addition (michael Addition); Examples Of Conjugate Addition; Reaction With Amines And Thiols; Self-assessment; Chapter 9. Chemistry Of Aromatic Heterocyclic Compounds; Aromaticity In Heterocyclic Compounds; Naming Of Heteroaromatic Compounds; The Basicity Of Nitrogen Heterocyclic Compounds. Van Der Waals Interactionshydrogen Bond Interactions; Molecular Affinity And The Free Energy Of Interaction; Self-assessment; Chapter 3. Acids And Bases; Definitions Of Acids And Bases; Acid And Base Strength; Quantifying The Strengths Of Acids And Bases: Pka And Pkb Values; Importance Of Acids And Bases In Pharmacy; Common Acidic And Basic Functional Groups; Ph And Pka; Amphoteric Compounds; Simple Buffer Solutions; Universal Buffer Solutions; Self-assessment; Chapter 4. Stereochemistry; Stereochemistry And Its Importance In Pharmaceutical Science; Stereoisomers. Fischer's Convention Of Stereochemical Nomenclatureconformational Isomers; Stereoisomers Of Cyclic Molecules; Geometric Isomers; Topological Isomers; Self-assessment; Chapter 5. Chemical Reaction Mechanisms; Nucleophiles And Electrophiles; Reaction Mechanisms; Curly Arrows In Reaction Mechanisms; Radicals In Reaction Mechanisms; Fish Hooks In Reaction Mechanisms; Chemical Reactivity; Self-assessment; Chapter 6. Chemistry Of Electrophiles And Nucleophiles; Addition And Substitution Reactions; Electrophilic Addition; Nucleophilic Substitution; Elimination Reactions. Competition Between Substitution And Eliminationself-assessment; Chapter 7. Chemistry Of Aromatic Compounds; Benzene; Naming Of Benzene Derivatives; Reactivity; Electrophilic Substitution; Electrophilic Substitution Versus Electrophilic Addition; Examples Of Electrophilic Substitution; Monosubstituted Benzene Derivatives; Halogen Substituents; Disubstituted Benzene Derivatives; Self-assessment; Chapter 8. Chemistry Of Carbonyl Compounds; Reactivity Of The Carbonyl Group; Nucleophilic Addition; Changes In Hybridisation During Nucleophilic Addition; Stereochemistry In Nucleophilic Addition. David Barlow, David Mountford.