Transporters as Drug Targets

Transporters as Drug Targets

Author
Harald H Sitte, Gerhard F Ecker, Gerd Folkers, Raimund Mannhold, Helmut Buschmann, Rasmus P Clausen
Language
English
Edition
1. Auflage
Year
2017
Page
334
ISBN
9783527333844,3527333843,9783527679430
File Type
pdf
File Size
19.2 MiB

As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.
Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation.
With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

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